Head of Programme- Somatic Genomics

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges. We are seeking an internationally recognised scientific leader to direct the Wellcome Sanger Institute’s Somatic Genomics Programme, one of our flagship research domains. This role offers the opportunity to define and deliver a bold, long-term scientific vision for understanding how somatic mutations arise, accumulate and shape human health across the lifespan. Sanger’s science is organised into a small number of major Programmes, each led by a Head of Programme with significant autonomy. Heads of Programme shape scientific direction, enable delivery through leadership and collaboration, and work within a distinctive non-tenure faculty model that allows scientific leadership to evolve over time. This is a leadership role focused on vision, people and impact, supported by world-class technical, operational and informatics teams. This appointment provides a rare opportunity to establish a transformative research agenda spanning the origins of cancer and non-neoplastic disease, ageing and mutational processes, leveraging Sanger’s unparalleled scale, technologies and collaborative environment.

About the Programme

The Somatic Genomics Programme aims to understand the causes and consequences of somatic mutations and epimutations, and their roles in health and disease. The Programme seeks to decipher fundamental processes of mutation, selection and clonal dynamics, and how these might be harnessed for prevention and therapeutic benefit. Building on Sanger’s world-leading contributions, the Programme will define a 10–15 year research trajectory across cancer and beyond oncology, with scope for significant technology development and broader impact across medicine and biology.

What you’ll do

• Set the scientific vision and strategy for the Programme and lead its delivery
• Recruit, support and develop core and associate faculty, fostering an inclusive, collaborative and high-performing environment
• Lead your own research group
• Guide and coordinate Programme research to ensure scientific excellence and sustainability
• Work in close partnership with technical, operational and informatics teams
• Contribute to the Institute’s Senior Leadership Team and strategic direction
• Build external collaborations and, where appropriate, pursue funding and partnerships

We welcome applicants from academia, industry, clinical and non-traditional career paths.

About you

We are seeking an established scientific leader with the experience and credibility to lead a major research Programme at scale, while fostering a supportive, inclusive and collaborative research environment.

Essential Skills and Experience

• Scientific Leadership & Expertise
• A strong record of research and scientific publication and impact in a relevant field, including the presentation and derivation of insight from genomic data.
• Recognised expertise and contribution within relevant scientific communities, appropriate to career stage.
• Significant scientific contributions demonstrated through high-quality research, innovation, or translational impact across academic, clinical, or industry settings.

Programme, Team & People Leadership Experience

Experience leading and developing scientific teams or research groups, with the ability to empower, mentor and support people from diverse backgrounds.

Ability to set a pioneering and forward-looking scientific vision for the Programme, and articulate a long-term strategic plan to deliver on that vision.

Demonstrated commitment to inclusive, respectful and values-led leadership, fostering an environment where people feel supported to do their best work.

Operational Delivery & Adaptability

Experience contributing to or leading complex, interdisciplinary programmes.

Ability to work adaptively and proactively with operational, technical and informatics colleagues to ensure effective programme delivery.

Understanding of responsible research practice, data governance and the stewardship of shared scientific resources.

Culture, Inclusion & Institute Values

Commitment to creating a culture grounded in openness, teamwork, adaptability and pioneering science, in line with the Institute’s values.

Ability to champion inclusive research culture through your leadership style, decision-making, and day-to-day interactions.

Willingness to actively contribute to organisational culture, including Sanger citizenship activities, Culture & Inclusion initiatives and Research Environment priorities.

Funding, Engagement & External Representation

Experience developing or contributing to external funding, partnerships or major collaborative initiatives, appropriate to career stage.

Ability to represent the Programme and Institute externally, strengthening strategic relationships with academic, clinical, industry and funding partners.

We welcome applicants with diverse leadership experiences, including from academia, industry, clinical roles and non-traditional career paths.

ClosingDate: 22nd April 2026

Location and relocation

We welcome applications from candidates based anywhere in the world. This role is based in the UK, with visa and relocation support available where required.

Hybrid Working at Wellcome Sanger

We recognise that there are many benefits to Hybrid Working; including an improved work-life balance, with more focused time, as well as the ability to organise working time so that collaborative opportunities and team discussions are facilitated on campus. The hybrid working arrangement will vary for different roles and teams. The nature of your role and the type of work you do will determine if a hybrid working arrangement is possible.

Equality, Diversity and Inclusion

We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers, Disability and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others. We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That’s why we’re committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

Our Benefits

We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute. Sanger Institute became a signatory of the International Technician Commitment initiative In March 2018. The Technician Commitment aims to empower and ensure visibility, recognition, career development and sustainability for technicians working in higher education and research, across all disciplines. Life at the Sanger Institute is unique. We are tackling some of the most difficult challenges in genomic research. Our people are shaping the future by delivering life-changing science with the reach, scale, and creativity to solve some of humanity’s greatest challenges. We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We offer an attractive benefits package at the Wellcome Sanger Institute. We appreciate the importance of achieving work-life balance and support this with a number of family and carer-friendly policies. Plus a flexible working policy for those who may wish to amend their working pattern or arrangement. Each year, the Wellcome Sanger Institute welcomes researchers from around the world to the Genome Campus to collaborate and drive cutting‑edge science. Whether you're joining as faculty, a postdoc, or a visitor, our dedicated International Team offers expert guidance and support throughout your journey, promoting the Institute’s global and collaborative ethos.

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