Senior Scientist, Drug Metabolism and Pharmacokinetics (DMPK)

About the Role

Our client is looking for an experienced Senior Scientist to join their expert Drug Metabolism and Pharmacokinetics (DMPK) team in Sheffield . This critical role will involve overseeing and conducting studies to characterize the absorption, distribution, metabolism, and excretion (ADME) properties of novel drug candidates. You will play a key part in guiding lead optimization and development decisions by providing robust DMPK data and insights. The ideal candidate will possess a strong scientific understanding of drug disposition and a commitment to high-quality research within a collaborative and dynamic pharmaceutical research setting.

Key Responsibilities

• Design, execute, and interpret in vitro and in vivo DMPK studies.
• Characterize drug metabolism pathways, transporter interactions, and pharmacokinetic profiles.
• Utilize LC-MS/MS for bioanalysis of drug and metabolite concentrations in biological matrices.
• Contribute to the selection and progression of drug candidates based on DMPK properties.
• Author study reports and contribute to regulatory submissions.
• Collaborate with medicinal chemists, pharmacologists, and toxicologists.

Requirements

• PhD in Pharmaceutical Sciences, Biochemistry, or a related discipline.
• Minimum of 5 years of experience in DMPK research within the pharmaceutical or biotech industry.
• Strong understanding of drug metabolism, pharmacokinetics, and bioanalysis.
• Hands-on experience with LC-MS/MS and relevant software.
• Ability to design and conduct complex DMPK studies.
• Excellent written and verbal communication skills.

Benefits

• Competitive salary and bonus opportunities.
• Comprehensive health, dental, and vision insurance.
• Pension scheme with employer contributions.
• Generous annual leave and company holidays.
• Support for professional development and continued education.