Principal Scientist - Drug Metabolism and Pharmacokinetics (DMPK) (Remote)

About the Role

Our client is looking for an exceptional Principal Scientist specializing in Drug Metabolism and Pharmacokinetics (DMPK) to join their globally distributed research team on a fully remote basis. This senior position is crucial for guiding the DMPK strategy of drug candidates, ensuring optimal absorption, distribution, metabolism, and excretion profiles. You will be responsible for designing and interpreting complex studies, contributing critical data to guide preclinical and early clinical development decisions. This is an outstanding opportunity for a seasoned DMPK expert to influence the direction of innovative therapeutics from anywhere within the UK .

Key Responsibilities

• Lead the design, execution, and interpretation of in vitro and in vivo DMPK studies for small molecule and biologic drug candidates.
• Develop and validate bioanalytical methods for the quantification of drug candidates and their metabolites in biological matrices.
• Integrate DMPK data with other preclinical and clinical data to build robust pharmacokinetic models and predict human pharmacokinetics.
• Provide strategic recommendations on candidate selection and optimization based on DMPK properties.
• Collaborate with toxicology, pharmacology, and clinical development teams to ensure a cohesive development strategy.
• Author study reports, contribute to regulatory submissions, and present findings to internal and external stakeholders.

Requirements

• Ph.D. in Pharmaceutical Sciences, Biochemistry, Pharmacology, or a related field.
• 10+ years of experience in DMPK research within the pharmaceutical or biotechnology industry.
• In-depth knowledge of drug metabolism pathways, transporter interactions, and pharmacokinetic principles.
• Expertise in bioanalytical method development and validation (e.g., LC-MS/MS).
• Proven experience in guiding drug development programs from a DMPK perspective.
• Exceptional communication and problem-solving skills, with a strong track record of successful remote collaboration.

Benefits

• Highly competitive salary and attractive bonus potential.
• Full remote working arrangement with flexible hours.
• Comprehensive private medical, dental, and vision insurance.
• Generous stock options and retirement savings plan.
• Significant budget for professional development, including conferences and workshops.
• Opportunity to work on groundbreaking projects with a world-class team.