Principal Scientist - Drug Metabolism and Pharmacokinetics (DMPK)

About the Role

Our client, a world-renowned pharmaceutical research institution, is seeking an accomplished Principal Scientist to lead their Drug Metabolism and Pharmacokinetics (DMPK) group in the vibrant scientific hub of Cambridge . This senior role is instrumental in guiding the DMPK strategy for novel drug candidates, ensuring their appropriate absorption, distribution, metabolism, and excretion profiles. You will play a critical part in drug discovery and development, providing expert scientific leadership and contributing to the selection and progression of compounds with favourable pharmacokinetic properties. This is a unique opportunity for an experienced DMPK scientist to drive innovation, mentor a talented team, and significantly influence the trajectory of new medicines within a collaborative and cutting-edge research environment in Cambridge .

Key Responsibilities

• Provide expert scientific leadership and strategic direction for the DMPK team, overseeing all aspects of drug metabolism and pharmacokinetic studies.
• Design and interpret complex in vitro and in vivo DMPK studies to assess drug candidate properties.
• Develop and validate bioanalytical methods to support pharmacokinetic studies.
• Collaborate closely with discovery chemistry, pharmacology, toxicology, and clinical development teams to integrate DMPK data into drug discovery and development strategies.
• Contribute to the preparation of regulatory submission documents (e.g., INDs, NDAs) with respect to DMPK data.
• Mentor junior scientists and foster a culture of scientific excellence, innovation, and collaboration within the DMPK department in Cambridge .

Requirements

• PhD in Pharmaceutical Sciences, Biochemistry, Analytical Chemistry, or a related discipline.
• Minimum of 8 years of experience in Drug Metabolism and Pharmacokinetics (DMPK) within the pharmaceutical industry.
• Proven track record of successfully contributing to the progression of drug candidates through discovery and development.
• Expertise in in vitro ADME assays, bioanalysis, and in vivo pharmacokinetic modeling and simulation.
• Strong understanding of drug discovery and development processes.
• Excellent leadership, communication, and problem-solving skills.

Benefits

• Highly competitive salary and generous bonus structure.
• Comprehensive health, dental, and vision insurance.
• Exceptional pension scheme and long-term incentive plans.
• Significant investment in professional development and conference participation.
• A stimulating, collaborative, and flexible hybrid working environment at the forefront of pharmaceutical innovation in Cambridge .