Senior Director, Late Oncology - Remote (US/UK)

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Jazz Pharmaceuticals is a global biopharma company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases — often with limited or no therapeutic options. We have a diverse portfolio of marketed medicines, including leading therapies for sleep disorders and epilepsy, and a growing portfolio of cancer treatments. Our patient-focused and science-driven approach powers pioneering research and development advancements across our robust pipeline of innovative therapeutics in oncology and neuroscience. Jazz is headquartered in Dublin, Ireland with research and development laboratories, manufacturing facilities and employees in multiple countries committed to serving patients worldwide. Please visit

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The Senior Director, Head of Late Oncology Program Management is a pivotal strategic and operational leadership role within Global Clinical Development Operations (GCDO). Reporting directly to the Executive Director, Head of Clinical Operations, the incumbent will serve as a key member of the Clinical Operations Leadership Team, shaping the vision, operational strategy, and execution framework for Jazz Pharmaceuticals’ late-stage oncology / early phase clinical trial portfolio.  This role requires a seasoned leader capable of bridging high-level strategic vision with granular technical detail. The Senior Director will partner closely with Clinical Development leadership in early program and study design, ensuring seamless execution planning, operational feasibility, and alignment with therapeutic area strategy. Additionally, the Senior Director will have a key role in reviewing comprehensive budgets and timelines in support of drug project governance and portfolio decision-making.

Essential Functions/Responsibilities

Strategic Leadership & Organizational Vision Collaboration

Define and articulate the strategic vision and long-term direction for  Late Oncology Program Management / Early Phase Program Management, aligned with Clinical Operations, GCDO and broader R&D strategic goals.

Serve as an active and impactful member of the Clinical Operations Leadership Team, contributing to overall department governance, resource planning, and operational excellence.

Foster a high-performance, inclusive culture across the Late Oncology Program Management / Early Phase Program Management organization, embedding accountability, continuous learning, and operational agility.

Portfolio Study Delivery & Operational Oversight

Ensure seamless end-to-end execution and operational delivery of complex, late-phase (Phase 2b/3/4 and pivotal) oncology clinical trials on schedule, within scope, and on budget.

Drive operational excellence, risk management, and proactive mitigation strategies across all late oncology trials to address potential portfolio risks.

Establish robust analysis of options and champion data-driven decision-making frameworks to navigate trial execution challenges effectively.

Cross-Functional & Enterprise Partnering

Establish highly effective collaborative partnerships across Clinical Operations, Global Clinical Development Operations (GCDO), Clinical Development, Medical Affairs, Regulatory Affairs, Biometrics, Safety, and broader R&D leadership.

Build strong working relationships with external partners, including Contract Research Organizations (CROs), academic research networks, trial steering committees, and Key Opinion Leaders (KOLs).

Maintain a strong enterprise perspective, balancing functional excellence with broader strategic and business objectives.

Contribute to operational feasibility assessments and early execution planning during study concept and protocol development phases to ensure robust, deliverable trial designs.

Governance, Financial Oversight & Budgetary Control

Develop, review, and defend global clinical program budgets and integrated timelines for presentation to drug project governance committees and R&D executive leadership.

Oversee financial planning, trial forecasting, resource allocation, and contribute to cost optimization initiatives across all global clinical trials

Line Management & Capability Building

Provide direct line management, leadership, mentorship, and career development to a high-performing team of Clinical Operations Directors and Associate Directors.

Embed high-performance practices, accountability, and continuous improvement into the culture of the study management organization.

Build and scale functional capabilities, ensuring Program Leads have the competencies, tools, and resources required to plan and execute complex trials.

Recruit, retain, and scale top-tier clinical operations talent to meet evolving portfolio demands and capability requirements.

Promote global team alignment and flexible resourcing models capable of operating seamlessly across international time zones and geographic regions.

Quality, Compliance & Inspection Readiness

Ensure all early-stage / late-stage oncology trials strictly adhere to ICH GCP guidelines, global regulatory standards, and internal Jazz Standard Operating Procedures (SOPs).

Drive a culture of continuous audit and inspection readiness across all trial management activities and clinical documentation.

Contribute to audits, inspections, and regulatory queries, ensuring prompt resolution of any quality or compliance findings.

Innovation, Digital Transformation & Process Optimization

Drive the integration of innovative clinical trial methodologies, including Decentralized Clinical Trials (DCTs), patient-centric execution models and pragmatic trial designs.

Chamption the adoption of advanced digital solutions, automated workflows, and predictive AI analytics to enhance risk-based oversight, enrollment forecasting, operational planning and resource productivity.

Continuously evaluate and optimize operational workflows, driving process simplification, modernization of SOPs, and agile ways of working.

Required Knowledge, Skills, and Abilities

Portfolio Track Record (Late Oncology): Proven, repeatable track record of successfully delivering complex clinical trials and multi-country clinical trial portfolios, specifically in late-stage (Phase 2/3/4) oncology development.

Clinical Development Partnership: Demonstrated experience partnering directly with Clinical Development Leads to shape program strategy / study design, protocol feasibility, and overall execution planning.

Governance & Budgeting: Proven track record of developing, presenting, and overseeing multi-million dollar clinical trial budgets and complex timelines to support formal drug project governance.

Functional Leadership: Substantial experience in leadership roles within a global study management or clinical operations organization within the pharmaceutical, biotech, or CRO industry.

Strategic Capability: A demonstrated track record of strategic function leadership, organizational design, and departmental vision setting. (Desirable)

Technical & Enterprise Balance: Demonstrated ability to manage complex technical details within the function while consistently maintaining a strategic enterprise perspective.

Strategic Partnering: Skilled at collaborating with Clinical Development and medical experts to translate scientific concepts into operationally viable study designs and execution plans.

Governance & Financial Acumen: Adept at constructing, analyzing, and presenting integrated program / study budgets and timelines for high-level governance review and strategic decision-making.

Self-Starter & Results-Driven: A highly motivated, resilient self-starter with a proactive approach to solving complex operational challenges.

Global Mindset & Flexibility: Proven capability to operate effectively across a matrixed global environment, requiring time zone flexibility to support multi-regional teams and study sites.

High-Performance Culture Builder: Demonstrated ability to inspire, motivate, and embed high-performance practices within a growing study management organization.

Communication & Influencing: Superior communication, negotiation, and stakeholder management skills, capable of influencing decisions at executive leadership levels.

Required/Preferred Education and Licenses

Advanced degree (Ph.D., Pharm.D., M.S., or equivalent) in a life sciences, clinical research, or healthcare-related discipline preferred. A Bachelor’s degree with exceptional industry experience will also be considered.

Significant biopharmaceutical industry experience in clinical trial operations, with significant senior leadership responsibility in Global Study management.

Direct line management (required), including leadership of people managers (preferred)

Closing date for applications is November 6

Jazz Pharmaceuticals is an equal opportunity/affirmative action employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any characteristic protected by law.

For Us Based Candidates Only

Jazz Pharmaceuticals, Inc. is committed to fair and equitable compensation practices and we strive to provide employees with total compensation packages that are market competitive. For this role, the full and complete base pay range is: $(phone number removed) - $(phone number removed)

Individual compensation paid within this range will depend on many factors, including qualifications, skills, relevant experience, job knowledge, and other pertinent factors. The goal is to ensure fair and competitive compensation aligned with the candidate's expertise and contributions, within the established pay framework and our Total Compensation philosophy. Internal equity considerations will also influence individual base pay decisions. This range will be reviewed on a regular basis.

At Jazz, your base pay is only one part of your total compensation package. The successful candidate may also be eligible for a discretionary annual cash bonus or incentive compensation (depending on the role), in accordance with the terms of the Company's Global Cash Bonus Plan or Incentive Compensation Plan, as well as discretionary equity grants in accordance with Jazz's Long Term Equity Incentive Plan.

The successful candidate will also be eligible to participate in various benefits offerings, including, but not limited to, medical, dental and vision insurance, 401k retirement savings plan, and flexible paid vacation. For more information on our Benefits offerings please click here